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刘小平
刘小平

刘小平 研究员

单位:澳门金莎娱乐网站(威海) 澳门金莎娱乐网站院

研究方向

生物大数据的挖掘与分析

人工智能在计算生物学中的应用

生物信息学

 

专利

1)陈洛南,刘小平,合原一幸,基于单样本数据的个体特异性网络构建方法和装置,2019.6.18,中国,ZL201510058477.X

 



联系方式
地址:山东省威海市文化西路180号澳门金莎娱乐网站院405室
电话: 17562600426   出生年月:1982年2月
Email: xpliu@sdu.edu.cn
行政职务与学术兼职
中国医药生物技术协会基因检测技术分会委员
第9、10、11届 International Conference on Systems Biology国际会议程序委员会委员
Scientific Reports, Neurocomputing, Journal of Theoretical Biology, IET Systems Biology, IEEE/ACM Transactions on Computational Biology and Bioinformatics等杂志特邀审稿人
学习经历
2009,9–2012,7 上海大学系统生物技术研究所 信息学与系统生物学    工学博士
2005,9–2008,6 新疆大学生命科学和技术学院 生物化学与分子生物学  理学硕士
2000,9–2004,7 烟台大学化学生物理工学院  生物科学              理学学士
工作经历
2017.06 –至今       澳门金莎娱乐网站(威海)澳门金莎娱乐网站院    研究员
2015.02 – 2017.03     日本東京大学生産技術研究所 特任研究员 合作导师:合原一幸
2012.08 – 2016.08     中科院上海生命科学研究院  博士后     合作导师:陈洛南
2012.12 – 2014.03    日本東京大学生産技術研究所 特任研究员 合作导师:合原一幸 
项目
1.       国家自然科学基金青年基金,61403363,批准时间:2014年,26万,主持
2.       中国博士后特别资助基金,2014T70441,批准时间:2014年,15万,主持
3.       中国博士后基金,2013M541565,批准时间:2013年,5万,主持
4.       mTOR调控网络在衰老及其相关代谢疾病发生进程中的作用及分子机制,973计划项目,2014CB910500,批准时间:2013年,学术骨干
5.       基于多组学谱特征的前列腺癌分子分型研究,国家重点专项,2016YFC09022,批准时间:2016年,项目骨干 
论著
29. Yanhong Huang, Xiao Chang, Yu Zhang, Luonan Chen*, Xiaoping Liu*, "Disease characterization using a partial correlation-based sample-specific network", Briefings in Bioinformatics, bbaa062, 2020, https://doi.org/10.1093/bib/bbaa062. (IF 9.101)

28. Yichong Wu, Tiejun Li, Xiaoping Liu, Luonan Chen, "Differential network inference via the fused D-trace loss with cross variables", Electronic Journal of Statistics, 14:1269-1301, 2020. (IF 0.986)

27. Fuyan Hu, Wenying Zeng, Xiaoping Liu*, "A Gene Signature of Survival Prediction for Kidney Renal Cell Carcinoma by Multi-Omic Data Analysis", International Journal of Molecular Science, 20(22): 5720, 2019. (IF 4.183)

26.  Xiaoqiang Sun*, Xiaoping Liu, Mengxue Xia, Yongzhao Shao*, Xiaohua Douglas Zhang*, "Multicellular gene network analysis identifies a macrophage?related gene signature predictive of therapeutic response and prognosis of gliomas", Journal of Translational Medicine, 17:159, 2019. (IF 4.098)

25.  Fuping Zhang, Xiaoping Liu, Aidi Zhang, Zhonglin Jiang, Luonan Chen*, Xiujun Zhang*, "Genome-wide dynamic network analysis reveals a critical transition state of flower development in Arabidopsis", BMC Plant Biology, 19:11, 2019. (IF 3.67)

24.  Bo Hu, Xiao Chang, Xiaoping Liu*, "Predicting Functional Modules of Liver Cancer Based on Differential Network Analysis", Interdiscip Sci Comput Life Sci, 11(4): 636-644, 2019. (IF 1.418)

23.   Xiaoping Liu, Xiao Chang, Siyang Leng, Hui Tang, Kazuyuki Aihara*, Luonan Chen*, "Detection for disease tipping points by landscape dynamic network biomarkers", National Science Review, 6(4): 775-785, 2019. (IF 13.222)

22.   Shenghui Liu, Chunrui Xu, Yusen Zhang*, Jiaguo Liu, Bin Yu, Xiaoping Liu*, Matthias Dehmer, "Feature selection of gene expression data for Cancer classification using double RBF-kernels", BMC Bioinformatics, 19:396, 2018. (IF 2.511)

21.   Jifan Shi, Juan Zhao, Xiaoping Liu, Luonan Chen*, Tiejun Li*, "Quantifying direct dependencies in biological networks by multiscale association analysis", IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2018, doi:10.1109/TCBB.2018.2846648. (IF 2.428)

20.    Ben-gong Zhang, Weibo Li, Yazhou Shi, Xiaoping Liu, Luonan Chen*, "Detecting causality from short time-series data based on prediction of topologically equivalent attractors", BMC Syst Biol, 11(Suppl 7): 128, 2017. (IF 2.05)

19.    Pei Chen, Yongjun Li, Xiaoping Liu, Rui Liu*, Luonan Chen*, "Detecting the tipping points in a three-state model of complex diseases by temporal differential networks", J Transl Med, 15: 217, 2017. (IF 4.197)

18.    Xiaoping Liu, Xiao Chang, Rui Liu, Xiangtian Yu, Luonan Chen*, Kazuyuki Aihara*, "Quantifying critical states of complex diseases using single-sample dynamic network biomarkers", PLOS COMPUT BIOL, 13(7): e1005633, 2017. (IF 3.955)

17.   Xiaoping Liu, Yuetong Wang, Hongbin Ji*, Kazuyuki Aihara*, Luonan Chen*, "Personalized characterization of disease using sample-specific networks", NUCLEIC ACIDS RES, 44(22): e164, 2016. (IF 10.162)

16.   Xiaoping Liu, Xiao Chang*, "Identifying module biomarkers from gastric cancer by differential correlation network", ONCOTARGETS THER, 2016(9): 5701-5711, 2016. (IF 2.612)

15.   Tao Zeng, Wanwei Zhang, Xiangtian Yu, Xiaoping Liu, Meiyi Li and Luonan Chen*, "Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals", BRIEF BIOINFORM, 17(4):576-592, 2016. (IF 5.134)

14.   Jiye Wang, Mi Li, Yun Wang, Xiaoping Liu, "Integrating subpathway analysis to identify candidate agents for hepatocellular carcinoma", ONCOTARGETS THER, 2016(9): 1221-1230, 2016. (IF 2.612)

13.   Qianqian Shi#, Xiaoping Liu#, Tao Zeng, William Wang, Luonan Chen*, "Detecting disease genes of non-small lung cancer based on consistently differential interactions", CANCER METAST REV, 34(2):195-208, 2015. (#Co-first authors, IF 5.316)

12.   Wanwei Zhang, Tao Zeng, Xiaoping Liu, Luonan Chen*, "Diagnosing phenotypes of single-sample individuals by edge biomarkers", J MOL CELL BIOL, 7(3): 231-241, 2015. (IF 6.459)

11.   Duojiao Wu#, Xiaoping Liu#, Chen Liu, Zhiping Liu, Ming Xu, Ruiming Rong, Mengjia Qian, Luonan Chen*, Tongyu Zhu*, "Network analysis reveals roles of inflammatory factors in different phenotypes of kidney transplant patients", J THEOR BIOL, 362: 62-68, 2014. (#Co-first authors, IF 2.116)

10.   Andrew E. Teschendorff*, Xiaoping Liu, Helena Caren, Steve M. Pollard, Stephan Beck, Martin Widschwendter, Luonan Chen, “The Dynamics of DNA Methylation Covariation Patterns in Carcinogenesis”, PLOS COMPUT BIOL, 10(7): e1003709, 2014. (IF 4.829)

9.   Rui Liu, Xiangtian Yu, Xiaoping Liu, Dong Xu, Kazuyuki Aihara*, and Luonan Chen*, "Identifying critical transitions of complex diseases based on a single sample", BIOINFORMATICS, 30(1): 1579-1586, 2014. (IF 4.981)

8.   ZENG Tao, ZHANG WanWei, YU XiangTian, LIU XiaoPing, LI MeiYi, LIU Rui & CHEN LuoNan*, “Edge biomarkers for classification and prediction of phenotypes”, SCI CHINA LIFE SCI, 57: 1103–1114, 2014. (IF 1.688)

7.   Xiaoping Liu, Jiguang Wang, Luonan Chen*, "Whole-exome sequencing reveals recurrent somatic mutation networks in cancer", CANCER LETT, 340:270-276, 2013. (IF 5.016)

6.   Xiaoping Liu, Xiaodong Zhang, Wei-Hua Tang, Luonan Chen* and Xing-Ming Zhao*, "eFG: an electronic resource for Fusarium graminearum", DATABASE-OXFORD, Vol. 2013: bat042, 2013, doi:10.1093/database/bat042. (IF 4.457)

5.   Xiaoping Liu, Rui Liu, Xing-Ming Zhao*, Luonan Chen*, "Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers", BMC MED GENOMICS, 6(Suppl 2):S8, 2013. (IF 3.914)

4.   Xiaoping Liu, Zhi-Ping Liu, Xing-Ming Zhao*, Luonan Chen*, "Identifying disease genes and module biomarkers by differential interactions", J AM MED INFORM ASSN, 19: 241-248, 2012. (IF 3.571)

3.   Achyut Sapkota, Xiaoping Liu, Xing-Ming Zhao, Yongwei Cao, Jingdong Liu, Zhi-Ping Liu and Luonan Chen*, "DIPOS: database of interacting proteins in Oryza sativa", MOL BIOSYST, 7: 2615-2621, 2011. (IF 3.534)

2.   Xiaoping Liu, Wei-Hua Tang, Xing-Ming Zhao*, Luonan Chen*, "A network approach to predict pathogenic genes for Fusarium graminearum", PLOS ONE, 5(10): e13021, 2010. (IF 4.411)

1.   Xiaoping Liu, Jiye Wang, Ping Gou, Cungui Mao*, Zeng-Rong Zhu*, Hongye Li*, "In vitro inhibition of postharvest pathogens of fruit and control of gray mold of strawberry and green mold of citrus by aureobasidin A", INT J FOOD MICROBIOL, 119: 223–229, 2007. (IF 2.753)
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